眼科学报2001，Vol.17Issue(1)：21-26,6.
Experiment Study of Effect of Perfiuorohexyloctane on Corneal Endothelial Cells
Experiment Study of Effect of Perfiuorohexyloctane on Corneal Endothelial Cells
Xiaoyan Ding 1Chunfang Li 1Lin Lu 1Guanguang Feng 1Huling Zheng1
作者信息
- 1. Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Science,
- 折叠
摘要
Abstract
Purpose: To investigate the effect of Perfluorohexyloctane (F6H8)on corneal endothelial celIs(CEC) of rabbit eyes.
Methods: Fifteen New Zealand white rabbits were devided into two groups:experimental group(F6H8) and control group(BSS) . All rabbits underwent anterior chamber injection of 0. 15ml F6H8 or BSS. Slit-lamp biomicroscopy and corneal endothelium photography were performed pre-operatively and postoperatively. Histopathological examination and Transmission electron microscopy(TEM) were done after the rabbits were sacrificed.
Results: All the corneas were clear. Since 4 weeks after operation, the endothelial cells were markedly irregular in size and shape and the number of endothelial cells was markedly decreased. Multilayered retrocorneal membranes (RCM)grew gradually 2 weeks after surgery. Vacuolar degeneration was seen in some endothelial cells. Nuclear degeneration and edema of plasma were seen in TEM.
Conclusion: Corneal endothelial cell degenerated after contacting with F6H8 for 2 ～4weeks. As a silicone solvent, it should be removed completely after injection. We don't recommend it to be used as a new intraocular temponade. Eye Science 2001: 17:21 ～ 26.关键词
corneal endothelial cell/Perfluorohexyloctane/histopathologyKey words
corneal endothelial cell/Perfluorohexyloctane/histopathology分类
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Xiaoyan Ding,Chunfang Li,Lin Lu,Guanguang Feng,Huling Zheng..Experiment Study of Effect of Perfiuorohexyloctane on Corneal Endothelial Cells[J].眼科学报,2001,17(1):21-26,6.
