摘要
Abstract
Objective To investingate the features of insulim resistance in elderly hypertensive patients. Methods The levels of serum toatal eholesterol(TC),serum triglycedde(TG),fasfing blood glnsose(FBG),2h postprandial blood glucose(PBG),fasting insulin (FINS),2h postprandial insulim (PINS),intracellular free calcium of lymphocyte ([Ca2+i) were respecfived measured,then the insulin sensitivity index (ISI) wad calculated,and compared in 60 essential hypertensive patients (30 elderly,30 non-elderly) and 20 weight index matched normotensive control subjects. Results (1)the hypertensive patients compared with normotensive control subjects,the patients had hyperinsumlinemia,insulin resistance and multiple metabolic disorders. (2)The elderly hypertensive patients compared with the non-elderly hypertensive patients,the levels of TG,FBG,PBG,FINS,PINS and [Ca2+]i were Significantly higher but ISI was significantly lower,in the elderly hypertensive patients. Conclusion The elderly hypertensive patients had more obvious hyperonsulinemia,severe insulin resistance and multiple metaboie disorders,these maybe related to aging and degeneracy.关键词
胰岛素抵抗/高血压病/老年人/高胰岛素血症/代谢紊乱/增龄Key words
Insulin resistance/Essential hypertension/The elderly/Hyperinsumlinemia/Metabolic disorders/Aging分类
医药卫生
