首页|期刊导航|中华医学杂志（英文版）|Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity
中华医学杂志（英文版）2007，Vol.120Issue(23)：2138-2142,5.
Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity
Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity
摘要
Abstract
Objective To review the research progress on Type IV secretion system (T4SS) in Helicobacter pylori.Data sources The data used in this review were identified by searching of PUBMED (1995-2007) online resources Study selection Mainly original articles and critical reviews written by major pioneer investigators of this field were selected.Results The research progress on T4SS in Helicobacter pylori was summarized.The structure and function was discussed.Conclusions T4SS is not only involved in toxin secretion and injection of virulence factors into eukaryotic host target cells,but also involved in horizontal DNA transfer to other bacteria and eukaryotic cells,through DNA uptake from or release into the extracellular milieu.It provides a new insight into the pathogenicity of Helicobacter pylori and a novel target for antimicrobials development.However,many challenges remain for us in understanding the biological role of T4SS in Helicobacter pylori.关键词
Helicobacter pylori/type IV secretion system/natural transformationKey words
Helicobacter pylori/type IV secretion system/natural transformation分类
医药卫生引用本文复制引用
ZHONG Qiao,SHAO Shi-he,CUI Lei-lei,MU Run-hong,JU Xiao-li,DONG Su-rong..Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity[J].中华医学杂志（英文版）,2007,120(23):2138-2142,5.基金项目
This study was supported by the Research Plan of Jiangsu Provincial Technology Commission (No.BS2004021) and the Advanced Talent Research Plan of Jiangsu University (No.JDG2004008). （No.BS2004021）
