中国病理生理杂志2001，Vol.17Issue(3)：215-218,4.
补肾活血泄浊汤治疗大鼠局灶性节段性
肾小球硬化的研究
Experimental study on treating rat focal segmental glomerulosclerosis
with Decoction of Bu-Shen-Huo-Xue-Xie-Zhuo
张悦 1魏民 2王谦 2楚非 2严京 2贾旭 2李伯光2
作者信息
- 1. 复旦大学医学院病理教研室,
- 2. 北京中医药大学病理教研室,
- 折叠
摘要
Abstract
AIM: To observe the effects of Decoction of Bu-Shen-Huo-Xue-Xie-Zhuo (BSHXXZ) on focal segmental glomerulosclerosis (FSGS) in rats. METHODS: Unilateral nephrectomy was adopted firstly, one week later adrimycin was intravenously adminstered to 20 rats twice in a 23-day period to establish an advanced focal segmental glomerulosclerosis model in the rat. Changes in urine protein, blood chemistry, and histology of the kidney were investigated for 110 days after unilateral nephrectomy. RESULTS: The BSHXXZ decoction reduced edema, proteinuria, hyperlipidemia, azotemia and ascites, and increased albumin in blood. Light microscopic, electron microscopic, immunohistochemical and polarizing microscopic examination all showed that the pathologic changes in the treatment group were less than that of the model group. CONCLUSION: Decoction of BSHXXZ could markedly improve renal function and delay the progression of glomerulosclerosis and renal interstitial fibrosis.关键词
肾小球硬化症,病灶性/中草药/治疗学/医学,中国传统分类
医药卫生引用本文复制引用
张悦,魏民,王谦,楚非,严京,贾旭,李伯光..补肾活血泄浊汤治疗大鼠局灶性节段性
肾小球硬化的研究[J].中国病理生理杂志,2001,17(3):215-218,4.
