南京医科大学学报(英文版)2003，Vol.17Issue(5)：215-219,5.
基质金属蛋白酶-7在卵巢浆液性肿瘤中的表达
Expression of Matrix Metalloproteinase-7 in Serous Ovarian Tumors
摘要
Abstract
Objective: To explore the expression of matrix metalloproteinase-7 in serous ovarian tumors. Methods:Expression of MMP-7 in 6 normal ovaries, 12 serous cystadenomas of ovary, 6 borderline cystadenomas of ovary, and 22 serous cystadenocarcinomas of ovary were studied by immunohistochemical SP staining. Results: No expression of MMP-7 was detected in normal ovaries. In most serous ovarian tumors, expression of MMP-7 was detected in both the cytoplasm of tumor cells and stroma, although it was reported in other tumors that MMP-7 was mainly expressed in the cytoplasm of tumor cells. The expression level of MMP-7 in the cytoplasm of tumor cells was statistically insignificant between serous cystadenomas of ovary, borderline cystadenomas of ovary, and serous cystadenocarcinomas of ovary. But in the stroma, the expression level of MMP-7 in borderline cystadenomas of ovary and serous cystadenocarcinomas of ovary was significantly higher than that in serous eystadenomas of ovary (P ＜ 0. 05). In borderline cystadenomas and serous cystadenocarcinomas of ovary, expression of MMP-7 could also be detected in the nuclei of some tumor cells. Conclusion: MMP-7 may play an important role in the progression of serous ovarian tumors.关键词
基质金属蛋白酶-7/免疫组织化学/卵巢肿瘤Key words
matrix metalloproteinase-7/immunohistochemistry/ovarian tumors分类
医药卫生引用本文复制引用
郭颖,刘军,宋天保..基质金属蛋白酶-7在卵巢浆液性肿瘤中的表达[J].南京医科大学学报(英文版),2003,17(5):215-219,5.基金项目
Supported by Grant from the Natural Science Foundation of Shaanxi Province (2001K10-G4) and Sci-entific Research Grant of the Second Hospital of Xi'an Jiaotong University(2001YJ-22) （2001K10-G4）
