中国临床康复2004，Vol.8Issue(11)：2156-2157,2.
马尾神经损害导致鞍区感觉障碍的病理机制
Pathological mechanism of sensory disturbance caused by cauda equina nerve damage
摘要
Abstract
AIM: To study the pathological mechanism of sensory disturbance caused by cauda equina nerve damage.METHODS: Fifty pure breed healthy male New Zealand rabbits were devided into three groups randomly: non-treatment group(10 rabbits);non-compression control group(10 rabbits) and trial group(30 rabbits) . At the following time points(1/4, 1/2, 3, 7 and 15 days). According to the of the compressor screw the sagittal diameter of vertebral canal, the model group was divided into 1/9, 2/9, 1/2. The compression devices were fixed between S2 and S3 to compress cauda equina. Posterior root ganglion was removed from the model with cauda equina nerve syndrome at different time point, and stained with HE. The number of normal sensory neuron cells were counted.RESULTS: After cauda equina nerve syndrome occurred for 1/2 day, there was ischemia and edema in two sides of posterior root ganglion and cellular necrosis of neurons in ganglion. The number of normal cells in posterior root ganglion was 3 and 7. The left in unoperation control group at time point of 30d was 32.2 ±4. 2, 32.2 ±4. 3, 32.2 ±4. 3/mm2; The left in uncomprssion operation group was 32.2 ± 2.3, 32.2 ± 4. 3, 32.2 ± 3.1/mm2; The left in experiment group was 17.2 ± 3.3, 14.2 ± 3.2, 14. 1 ± 2.3/mm2. There was significant difference between groups( P ＜ 0.05).CONCLUSION: Sensory neurons in posterior root ganglion are very sensitive and easily suffer necrosis, which is one of the important pathological changes of direct degeneration in cauda equina nerve damage and also explain why the numbness of sella turcica region and sensory disturbance are hard to recover.关键词
马尾/神经节,脊/神经节,感觉分类
医药卫生引用本文复制引用
史建刚,贾连顺,袁文,叶晓健,谭军,贾宁阳..马尾神经损害导致鞍区感觉障碍的病理机制[J].中国临床康复,2004,8(11):2156-2157,2.基金项目
全军医学科研"十五"规划课题(01L056) （01L056）
