中国临床康复2005，Vol.9Issue(8)：216-217,2.
氟西汀对乳腺癌抑郁症患者的干预效果
Interventional effect of fluoxetine on the quality of life in depressive patients with breast cancer
汤艳清 1丁宝坤 1李艳苓2
作者信息
- 1. 中国医科大学医学心理学和精神医学教研室,辽宁省,沈阳市,110001
- 2. 鞍山市中心医院心理科,辽宁省,鞍山市,116001
- 折叠
摘要
Abstract
BACKGROUND: There are many studies on the quality of life (QOL) of patients with breast cancer at home and abroad at present. But the effect of antidepressants on the QOL of depressive patients with breast cancer is not clear yet.OBJECTIVE: To investigate the effect of fluoxetine on the QOL of depressive patients with breast cancer.DESIGN: A self-controlled and observational comparative study of taking the patient as the subjects.SETTING: The research institute of medical psychology and psychiatric specialty in two universities and a psychiatric department in a city hospital.PARTICIPANTS: Sixty-three female post-operative patients with breast cancer hospitalized in the First Affiliated Hospital and Second Affiliated Hospital of China Medical University and Dalian Tumor Hospital, with an average age of (50 ± 9) years.INTERVENTIONS: Sity-three depressive patients with breast cancer were treated with fluoxetine for 8 weeks. Treatment emergent symptom scale (TESS) and relative laboratory examinations were used to evaluate the safety of fluoxetine to depression and anxiety of depressive patients with breast cancer. QOL of WHO scale was used to assess the QOL of the patients before and after administration.MAIN OUTCOME MEASURS:①Score of every index of QOL of WHO;②Side effects and adverse effects.RESULTS: The scores of physiology, psychology and independence in QOLafter 8 weeks' administration(16.30 ±2.17, 14.41 ± 1.85, 16. 90 ± 1.53)were significantly higher than those before grouping (13.61 ±2.46,12.98 ± 2.65, 13.65 ± 2.45) ( t = 6.52, P ＜ 0.01; t = 2.41, P＜ 0.05; t= 8.93, P ＜ 0.01 ). No obvious side effect was observed during administration.CONCLUSION: Fluoxetine can significantly improve the QOL of patients with breast cancer and there are fewer side effects during the treatment.关键词
氟西汀/乳腺癌/抑郁症/干预分类
医药卫生引用本文复制引用
汤艳清,丁宝坤,李艳苓..氟西汀对乳腺癌抑郁症患者的干预效果[J].中国临床康复,2005,9(8):216-217,2.
