中国临床康复2004，Vol.8Issue(11)：2184-2185,2.
人脑垂体腺瘤中Myc/Max/Mxil网络与其生物学行为及预后判断
Abnormality of the Myc/Max/Mxil network in human pituitary adenomas
傅震 1李伟1
作者信息
- 1. 南京医科大学附属第一医院神经外科,江苏省,南京市,210029
- 折叠
摘要
Abstract
AIM: To investigate the relationship between the expression of Myc, Max and Mxil proteins and human pituitary adenomas(hPA).METHODS: Totally 58 PA were classified as invasion and non-invasion PA, microadenomas and macroadenomas, recurrence and non-recurrence PA. Immunohistochemical assay was used to determine protein expression of c-Myc, Mxil and Max.RESULTS: Over expressed Myc protein was found in 45% of the 58 PA,and Mx il and Max failed to express in 90% and 86% of the PA respectively.The positive expressive ratio and level were statistically different between invasions and non-invasion group and between recurrence and non-recurrence group( P ＜ 0. 05). Of the 58 eases of PA, it was found that 31 cases had at least one protein abnormally expressed, comparing with only one case in 10 normal brain tissues.CONCLUSION: The abnormality of Myc/Max/Mxil network may be closely correlated with the occurrence and progress of PA, and play an important role in regulating cell proliferation and differentiation in PA. The expression of Myc protein can be used as a promising index in PA prognosis.关键词
垂体腺瘤/Myc/Max/Mxi1网络/免疫组织化学分类
医药卫生引用本文复制引用
傅震,李伟..人脑垂体腺瘤中Myc/Max/Mxil网络与其生物学行为及预后判断[J].中国临床康复,2004,8(11):2184-2185,2.
