中国临床康复2004，Vol.8Issue(11)：2190-2192,3.
MMP-2/MMP-9在乳腺癌组织中的表达及其与肿瘤浸润转移的关系
Expression of MMP-2 and MMP-9 in the tissues of breast carcinoma and its relationship with tumor invasion and metastasis
摘要
Abstract
BACKGROUND: Matrix melloproteinases play a pivotal role in tumor invasion and metastasis, but little is known about the correlation between their expression and the prngnosis of breast cancer.OBJECTIVE: To investigate the expression of matrix melloproteinases-2 and matrix melloproteinases-9 (MMP-2/MMP-9) and the distributive form of ColⅣ (type Ⅳ collagen)in the tissues of breast carcinoma, and find out their relationship with tumor invasion and metastasis so as to disclose the mechanism of the tumor invasion and metastasis of breast carcinoma.SETTING and PARTICIPANTS: Eighty-two filed wax masses of samples from the removed breast carcinoma and 30 filed wax messes of samples from the control group were collected at random from the First Affiliated Hospital of Fujian Medical University.MAIN OUTCOME MEASURE: The expression of MMP-2, MMP-9 and the distributive form of ColⅣ in the tissues of breast carcinoma and in the tissues without breast carcinoma, and the correlation of the results with clinicopathological tumor parameters.METHODS: Tissues were obtained from 82 patients with breast carcinoma and 30 without breast carcinoma. The expression of MMP-2, MMP-9 and the distributive form of ColⅣ were examined, and their correlation with clinicopathological tumor parameters was explored.82 cases of breast carcinoma were 52 % (43/82) and 54% (44/82) respectively. The distributive form of encapsulated ColⅣ was 15% (12/82),and the distributive form of decomposed ColⅣwas 85% (70/82), which were MMP-2/MMP-9 were related to the distribution form of ColⅣ( P ＜ 0. 05).lymph node (x2 =8. 1899, P ＜ 0. 05), and the expressions of MMP-2 was not related with the metastasis of the axillary lymph node(x2 = 3. 3590, P ＞0. 05).CONCLUSION: MMP-2, MMP-9 play a pivotal role in tumor invasion and metastasis. The result is suggested that detection of MMP-2/MMP-9 helps to judge the malignant severity of breast carcinoma and its biological behavior.关键词
乳腺肿瘤/免疫组织化学/基质金属蛋白酶/胶原分类
医药卫生引用本文复制引用
黄晓曦,许东坡,王力群,高凌云..MMP-2/MMP-9在乳腺癌组织中的表达及其与肿瘤浸润转移的关系[J].中国临床康复,2004,8(11):2190-2192,3.基金项目
福州市科委基金(99350104000340) （99350104000340）
