天然产物研究与开发2007，Vol.19Issue(2)：221-224,4.
甘草酸对猪呼吸道冠状病毒的抗病毒作用
Antiviral Effect of Glycyrrhizin on Porcine Respiratory Coronavirus (PRCV)
摘要
Abstract
The inhibitory effect of glycyrrhizin (GL) on porcine respiratory coronavirus ( PRCV ) replication was investigated in vitro in ST cells using RT-PCR and Western blot techniques. GL effectively suppressed PRCV replication without causing apparent cell cytotoxicity in ST cells. The inhibitory effect of GL on PRCV was in a dose-dependent manner.The expression levels of both mRNA and protein of the PRCV nucleocapsid protein in ST cells were impeded by the increasing addition of GL,suggesting it is a potential effective antiviral component against PRCV in vitro.关键词
甘草酸/核衣壳蛋白/猪呼吸道冠状病毒Key words
glycyrrhizin/nucleocapsid protein/porcine respiratory coronavirus (PRCV)分类
医药卫生引用本文复制引用
曹敏杰,吴国平,翁凌,苏文金..甘草酸对猪呼吸道冠状病毒的抗病毒作用[J].天然产物研究与开发,2007,19(2):221-224,4.基金项目
Foundation Item:This project was supported by a grant from the Bureau of Science and Technolohy of Fujian Province (2003N083), and a grant from the Bureau of Science and Technology of Xiamen City (3502Z20031054). （2003N083）
