吉林医药学院学报2009，Vol.30Issue(4)：222-227,6.
正常及患病心脏中的一氧化氮和一氧化氮合酶亚型
Nitric oxide and nitric oxide synthase isoforms in the normal and failing heart
李中言 1Soban Urma2
作者信息
- 1. 吉林医药学院附属医院心肾内科,吉林,吉林,132013
- 2. 吉林医药学院附属医院心肾内科
- 折叠
摘要
Abstract
We have reviewed the role of nitric oxide synthase(NOS)isoforms and nitric oxide(NO)in the normal heart and in heart failure.NO is a highly reactive siganaling molecule produced normally in the heart and is an important modulator of myocardial function.NOS catalyzes the conversion of L-arginine to L-citrulline and NO.In the heart,three NOS isoforms are present:neuronal NOS(nNOS),and endothelial NOS(eNOS),are constitutively present enzymes in distinct subcellular locations within cardiomyocytes,whereas inducible NOS(iNOS)is absent in the healthy heart,but its expression is induced by inflammation and immune responses.In the tissue,NO has two main effects:(i)it stimulates the activity of guanylate cyclase,and(ii)nitrosylates tyrosine residues in proteins and thiol-groups of cysteine in proteins.Changes in subcellular compartmentalization of NOS isoforms lead to the increased NO synthesis,reduction of the specificity of its effects,disruption of calcium homeostasis,electromechanical uncoupling and myocardial contractile failure.关键词
Nitric oxide/nitric oxide synthase/heart failureKey words
Nitric oxide/nitric oxide synthase/heart failure分类
医药卫生引用本文复制引用
李中言,Soban Urma..正常及患病心脏中的一氧化氮和一氧化氮合酶亚型[J].吉林医药学院学报,2009,30(4):222-227,6.
