汕头大学医学院学报2001，Vol.14Issue(1)：22-24,3.
汕头地区人群HLA-DRB1等位基因与类风湿关节炎的相关性研究
HLA-DRB1 Alleles Genotyping in Patients of Rheumatoid Arthritis in Shantou
林玲 1曾庆馀 1刘升云 1黄少弼 1肖征宇 1许杰洲 1杨泽 2孙逸平 2沈晶晶2
作者信息
- 1. 汕头大学医学院风湿病研究室
- 2. 卫生部北京老年医学研究所
- 折叠
摘要
Abstract
Objective:To investigate the relationship of HLA-DRB1 alleleswith the susceptibility and clinical features of rheumatoid arthritis(RA)in Shantou.Methods:One hundred and seventeen cases of RA were studied;the control group included 38 cases of systemic lupus erythematosus(SLE)and 100 healthy.DRB1 was typing by DNA amplification with sequence-specific primers(SSP).DRB1*04 subtypes were determined by hybridization with sequence-specific oligonucleotides probes(SSOP).Results：The prevalence rate of DRB1* 04 in RA was higher than that in the control group(49.6% vs 18.0%).The DRB1*0405 accounted for 62.1% of DRB1* 04 positive RA and 27.8% of positive healthy.Compared with DRB1*04 negative RA,the disease duration of positive ones was longer and the onset age was younger.No significant difference was found in the incidence rates of RF,ANA,APF,AKA,anti-RA33 antibodies,anti-Sa antibodies and anti-type II collagen antibodies between two groups.Conclusion:HLA-DRB1* 04 alleles and DRB1*0405 are significantly associated with RA susceptibility in Shantou.DRB1 alleles genotyping may be useful in evaluating the disease severity and prognosis of RA patients.关键词
关节炎/类风湿/HLA-DRB1等位基因分类
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林玲,曾庆馀,刘升云,黄少弼,肖征宇,许杰洲,杨泽,孙逸平,沈晶晶..汕头地区人群HLA-DRB1等位基因与类风湿关节炎的相关性研究[J].汕头大学医学院学报,2001,14(1):22-24,3.
