中国现代医学杂志2004，Vol.14Issue(24)：22-24,28,4.
病毒感染在慢性阻塞性肺病发病中作用的研究
Study on viral infection in patients with chronic obstructive pulmonary disease
靳长俊 1林殿杰 1辛洪涛 1杨兆辉 1陈玉娟1
作者信息
- 1. 山东大学山东省立医院,呼吸内科,山东,济南,250021
- 折叠
摘要
Abstract
Objective: To study the relationship between viral infection and chronic obstructive pulmonary disease (COPD), and the role of viral infection in the pathogenesis of COPD. Methods: Serum samples from 86 patients with acute exacerbation of COPD (Group A), 32 patients with stable COPD (Group B) were tested for the specific IgG and IgM for Respiratory Syncytial virus (RSV), Adenovirus (ADV), Coxsackievirus (COX) and Cytomegalovirus (CMV)with Biochip technique-indirect immunofluorescence test. T lymphocyte subsets (CD3, CD4, CD8) were studied by Alkaline phosphatase anti-alkaline phosphatase (APAAP). Results: The positive rates of IgM and IgG were no significant difference between group A and group B (P ＞0.05). In group A, the expression of CD3, CD4 and CD8 were significantly lower than those in group B (P ＜0.01 or P ＜0.05); In group A, the expression of CD3, CD4 in viral antibody positive groups were significantly lower than those in viral antibody negative groups (P ＜0.01 or P ＜0.05), but the expression of CD8 were not significantly different (P ＞0.05). Conclusions: The viral infection was common in acute exacerbation of COPD, and related to the pathogenic mechanism of COPD.关键词
肺疾病/阻塞性/病毒/T淋巴细胞亚群Key words
pulmonary disease/obstructive/virus/T lymphocyte subsets分类
医药卫生引用本文复制引用
靳长俊,林殿杰,辛洪涛,杨兆辉,陈玉娟..病毒感染在慢性阻塞性肺病发病中作用的研究[J].中国现代医学杂志,2004,14(24):22-24,28,4.
