中国现代医学杂志2004，Vol.14Issue(6)：22-25,4.
ELFP方案治疗晚期鼻咽癌及上消化道癌疗效分析
Analysis of curative effect of ELFP regimen on advanced nasopharyngeal carcinoma and upper digestive cancer
林懿 1林英城 1林雯1
作者信息
- 1. 汕头大学医学院附属肿瘤医院,内科,广东,汕头,515031
- 折叠
摘要
Abstract
Objective: To evaluate the clinical effects and toxicities of ELFP regimen in advanced nasopharyngeal carcinoma (NPC) and upper digestive cancer. Methods: 64 patients of NPC, esophagus carcinoma and gastric cancer proved by pathology were collected in this trial. All patients were treated for 2 ～ 6 cycles with ELFP regimen in which there were Vp - 16 0. 1g iv drip d1 -3, CF 0. 1 g iv drip d1 -3 and 5 - Fu 0.5 g iv drip d1 -3, DDP 50 mg iv drip d1-2, repeated every 21 days. Results: The response rates (CP + PR) in NPC, esophageal carcinoma and gastric cancer were 75%, 70% and 43.8%, respectively. The survival time was 3 ～ 41 months in all of 3 groups, median survival time was 11.5, 10 and 7.5 months in NPC, esophageal carcinoma and gastric cancer, respectively. Toxicity included mainly bone marrow suppression, 21.9% of grade Ⅲ and Ⅳ neutropenia, 15.6% of grade Ⅲ and Ⅳ hemoglobin decrease and 7.8% of grade Ⅲ and Ⅳ thrombocytopenia, as well as 7.8% of grade Ⅲ and Ⅳ of nausea and vomiting. Conclusion: ELFP is an effective and practicable regimen for advanced NPC esophagus carcinoma with tolerable toxicities.关键词
鼻咽癌/上消化道癌/化学治疗Key words
nasopharyngeal tumor/upper digestive cancer/chemotherapy分类
医药卫生引用本文复制引用
林懿,林英城,林雯..ELFP方案治疗晚期鼻咽癌及上消化道癌疗效分析[J].中国现代医学杂志,2004,14(6):22-25,4.
