东南大学学报（英文版）2001，Vol.17Issue(2)：22-26,5.
连接光异构化非天然氨基酸的RGD肽抑制细胞的附着
Cell Adhesion Inhibition by RGD Peptides Linked with a Photoisomerizable Nonnatural Amino Acid
张海黔 1原宽明 2顾宁 3佐々木裕司 2户昌彦2
作者信息
- 1. 吴健雄实验室,东南大学
- 2. 生物科学与技术系,冈山大学,
- 3. 吴健雄实验室,东南大学,
- 折叠
摘要
Abstract
RGD peptides linked with a nonnatural amino acid, phenylazophenyl alaninine (azoAla), were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C-terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the cell adhesion inhibition was further investigated. It was demonstrated that the cis-form of azoAla-linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans-form of azoAla-linked RGD peptide. 关键词
非天然氨基酸/细胞附着/光致异构化/肽分类
生物科学引用本文复制引用
张海黔,原宽明,顾宁,佐々木裕司,户昌彦..连接光异构化非天然氨基酸的RGD肽抑制细胞的附着[J].东南大学学报（英文版）,2001,17(2):22-26,5.
