生殖医学杂志2002，Vol.11Issue(z1)：22-28,7.
An investigation of acarbose effects in PCOS women with postprandial hyperglycemia
An investigation of acarbose effects in PCOS women with postprandial hyperglycemia
郑建淮 1曹缵孙 1陈晓燕 1毛文军1
作者信息
- 1. Research Laboratory of Reproductive Endocrinology, First Hospital of Xi'an Jiaotong University, Xi'an 710061
- 折叠
摘要
Abstract
Objectives: To investigate the effects of insulin resistance on serum androgen level and ovulation of women with polycystic ovary syndrome (PCOS) and observe clinic role of acarbose in the treatment of hyperinsulinemia, postprandial hyperglycemia and anovulation. Methods: 14 women accompanied by postprandial hyperglycemia with PCOS were administrated by acarbose for 12 weeks.14 age-matched individuals who had similar body mass index and normal menstruation were served as controls. Results: Serum T levels declined significantly from 4.09±1.04 nmol/L to 1.71±0.54 nmol/L (P<0.001), after acarbose treatment for 12 weeks. 12 out of 14 cases restored ovulation and menstrual cycles after acarbose treatment, among which 4 got pregnant. Conclusion: Acarbose may play a role on reducing postprandial hyperglycemia and HbAic levels, increase ISI and FSG/FI, indirectly reduce serum androgen levels through reducing plasma insulin level and recover ovarian ovulation in PCOS women with postprandial hyperglycemia.关键词
Polycystic ovary syndrome/Hyperinsulinemia/Postprandialhyperglycemia/AcarboseKey words
Polycystic ovary syndrome/Hyperinsulinemia/Postprandialhyperglycemia/Acarbose分类
医药卫生引用本文复制引用
郑建淮,曹缵孙,陈晓燕,毛文军..An investigation of acarbose effects in PCOS women with postprandial hyperglycemia[J].生殖医学杂志,2002,11(z1):22-28,7.
