中国药科大学学报2001，Vol.32Issue(3)：224-226,3.
侧柏叶醇提取物抗炎作用的研究
Study on the Anti-inflammatory Effect of Biota orientalis
梁统 1覃燕梅 2梁念慈2
作者信息
- 1. 广东天然药物研究开发实验室,
- 2. 广东医学院生化教研室,
- 折叠
摘要
Abstract
AIM The purpose is to investigate the Anti-inflammatory mechanism of Biota orientalis. METHODS Using rat leukocytes and rabbit platelets as experimental material the biosynthesis of leukotriene, 12-hydroxyheptadecatrienoic acid(12-HHT) and 12-hydroxyeicosatetraenoic acid(12-HETE) in the cells was determined with HPLC. RESULTS Biota orientalis was shown to inhibit the biosynthesis of leukotriene B4(LTB4) and 5-hydroxyeicosatetraenoic acid(5-HETE) with IC50 of 0.40 and 0.41 mg/ml crude herb, respectively. It was also displayed to inhibit biosynthesis of 12-HHT in the platelets. CONCLUSION Biota orientalis leaves contain anti-inflammatory components and the anti-inflammatory mechanism was related with inhibiting metabolism of arachidonic acid.关键词
侧柏叶/白三烯B4/12-羟十七碳三烯酸分类
医药卫生引用本文复制引用
梁统,覃燕梅,梁念慈..侧柏叶醇提取物抗炎作用的研究[J].中国药科大学学报,2001,32(3):224-226,3.
