中国现代医学杂志2006，Vol.16Issue(15)：2245-2248,4.
西洛他唑对2型糖尿病患者尿白蛋白排泄率的影响
Effect of Cilostazol on urinary albumin excretion rate in type 2 diabetic patients
摘要
Abstract
[Objective] To evaluate the efficacy of Cilostazol in treating incipient diabetic nephropathy in type 2diabetic patients. [Methods] Sixty cases of normotensive type 2 diabetes with microalbuminuria were randomized into two groups, 30 cases in each. The Cilostazol-treated group was orally given Cilostazol (50 mg, bid) for 3 months.Whereas, the control group received vitamin B1 (10 mg, bid) also for 3 months. Before and after the study, urinary albumin excretion rate (UAER) was investigated. [Results] In Cilostazol-treated group UAER was markedly decreased (P ＜0.01) by 51.6%. Renal and liver function tests were kept normal. Only 3% of the patients developed mild headache during Cilostazol treatment. By contrast, UAER did not show any significant change in control group(P＞0.05). [Conclusion] Cilostazol decreases urine albumin excretion efficiently in the diabetic patients with incipient diabetic nephropathy. Cilostazol is safe and well tolerated.关键词
糖尿病肾病/微量白蛋白尿/西洛他唑Key words
diabetic nephropathy/microalbuminuria/Cilostazol分类
医药卫生引用本文复制引用
高峰,胡秀芬..西洛他唑对2型糖尿病患者尿白蛋白排泄率的影响[J].中国现代医学杂志,2006,16(15):2245-2248,4.基金项目
Project supported by Returning Overseas Scholar Science Study Foundation, Ministry of Education of China (No: 2005383) （No: 2005383）
