国际眼科杂志2004，Vol.4Issue(2)：228-231,4.
肉毒杆菌毒素A治疗先天性眼球震颤22例
Effects of botulin A on 22 patients with congenital nystagmus
邓宏伟 1杨景存 1曹木荣2
作者信息
- 1. 518001,中国暨南大学深圳眼科中心
- 2. 450052,中国郑州大学第一附属医院眼科
- 折叠
摘要
Abstract
AIM: To investigate the effect of botulin A (BTA) on patients with congenital nystagmus (CN).METHODS: Twenty-two CN patients (44 eyes, including5 females and 17 males) were treated with BTA of the lowest effective dosage injected directly into the patients'correlative extrocular muscles. The changes in ocular nystagmus were measured by electronystagmography (ENG)before the BTA injection and one week, one month, three months, and half a year afterwards. Meanwhile the changes in visual acuity and three-degree visual function were also measured.RESULTS: Visual acuity at different time before and after the injection did not show significant changes (P＞0.05). Compared with the nystagmus data in the near-and far-distance primary positions before the injection, they all decreased significantly 1 month after the injection (P＜0.05). Compared with the nystagmus amplitude in the near-and far-distance primary positions before the injection, it decreased significantly three months and half a year after injection (＜0.05). The lowest intensity position, which reflected the changes of compensatory head postures, did not change obviously after injection, although it showed the tendency of becoming closer to the primary eye position. As for three-degree binocular vision, the fusion range amplified significantly 3 and 6months after injection (P＜0.05).CONCLUSION: This treatment of CN is proved effectivein reducing nystagmus at the primary eye position, improving the compensatory head postures, visual acuity and three-degree binocular vision to some extent. The most effective period occurs at one month after injection.The effect begins to reduce six months after the injection when compared with that at one month.关键词
肉毒杆菌素A/先天性眼球震颤/眼震电图Key words
botulin A/congenital nystagmus/electronystagmogram分类
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邓宏伟,杨景存,曹木荣..肉毒杆菌毒素A治疗先天性眼球震颤22例[J].国际眼科杂志,2004,4(2):228-231,4.
