中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(4)：229-231,3.DOI:10.1007/s10030-009-0020-z
C-kit:PDGFRα的表达与卵巢浆液性癌顺铂耐药的临床研究
Expression of C-Kit & PDGFRα and correlation with chemotherapy resistance in ovarian serous carcinomas: a clinical study
摘要
Abstract
Objective: To investigate the expression of C-Kit and PDGFRα and their correlation with chemotherapy resis-tance in ovarian serous carcinoma. Methods: We undertook SP immunohistochemical technique to examine the expression of C-Kit and PDGFRα in 59 cases with ovarian serous carcinomas, using archival paraffin-embedded specimens. Then we observed the correlation with chemotherapy resistance. Results: C-Kit and PDGFRα immunostainings were observed posi-tively expressed in 57.63% and 66.10% cases. C-Kit expression was statistically correlated with the progression of disease after first-line chemotherapy (P<0.05), but PDGFRa was not statistically significant (P > 0.05). There were great difference between of C-Kit and PDGFRa expressions in samples of different differentiated and clinical stages of ovarian serous carci-nomas (P<0.01 or P<0.05). Conclusion: C-Kit is statistically correlated with chemotherapy resistance, while PDGFRα is not correlated.关键词
C-Kit/PDGFRα/ovarian carcinomaKey words
C-Kit/PDGFRα/ovarian carcinoma分类
医药卫生引用本文复制引用
Cunjian Yi,Li Li,Ding Ma..C-kit:PDGFRα的表达与卵巢浆液性癌顺铂耐药的临床研究[J].中德临床肿瘤学杂志（英文版）,2009,8(4):229-231,3.基金项目
Supported by a grant from the Scientific Research Foundation of Health Department of Hubei Province (No. JX3C54). （No. JX3C54）
