中华医学杂志（英文版）2008，Vol.121Issue(22)：2299-2304,6.
Protective effect of ghrelin on left ventricular remodeling in spontaneously hypertensive rats is associated with the peroxisome proliferator-activated receptor gamma-dependent pathway
Protective effect of ghrelin on left ventricular remodeling in spontaneously hypertensive rats is associated with the peroxisome proliferator-activated receptor gamma-dependent pathway
LI Zhao 1ZHU Xiao-ying 1LI Meng 1BAI Ying-long 2HU Jian1
作者信息
- 1. Department of Cardiology,First Hospital Affiliated to China Medical University,Shenyang,Liaoning 110001,China
- 2. College of Public Health,China Medical University,Shenyang,Liaoning 110001,China
- 折叠
摘要
Abstract
Background Studies suggested that exogenous ghrelin administration could prevent eady left ventricular remodeling in rats with myocardial infarction.We investigated herein whether ghrelin attenuated left ventricular remodeling induced by hypertension and whether ghrelin's effect was mediated through the peroxisome proliferator-activated receptor gamma (PPAR-γ)-dependent pathway.Methods Spontaneously hypertensive rats (8-week-old males) were randomly divided into three groups with 12 rats in each:ghrelin group (received ghrelin 100 μg/kg subcutaneously (sc) twice daily);ghrelin+GW9662 group (received the PPAR-γ antagonist GW9662 at 2 mg/kg sc,and then ghrelin as above);saline controls.Normal male Wistar Kyoto rats (n=12) served as normal controls.Four weeks later,the effects of ghrelin on cardiac remodeling were evaluated by echocardiographic,hemodynamic,and histopathological examination,and gene expression analysis (PPAR-γ protein and mRNA expression).The serum levels of C-reactive protein (CRP) and tumor necrosis factor (TNF)αa were detected by enzyme linked immunosorbent assay.Results Ghrelin prevented ventricular remodeling,increased PPAR-y expression in the myocardium,suppressed collagen I and collagen III mRNA expression,and also decreased the serum levels of TNF-α,but not CRP.All abovementioned effects of ghrelin were inhibited by GW9662.Conclusion Ghrelin inhibited ventricular remodeling induced by hypertension,and the preventive effects of ghrelin may be mediated by the anti-inflammatory actions of the PPAR-y-dependent pathway.关键词
ghrelin/hypertension/collagen/peroxisome proliferator-activated receptor gamma/left ventricular remodelingKey words
ghrelin/hypertension/collagen/peroxisome proliferator-activated receptor gamma/left ventricular remodeling分类
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LI Zhao,ZHU Xiao-ying,LI Meng,BAI Ying-long,HU Jian..Protective effect of ghrelin on left ventricular remodeling in spontaneously hypertensive rats is associated with the peroxisome proliferator-activated receptor gamma-dependent pathway[J].中华医学杂志（英文版）,2008,121(22):2299-2304,6.
