中国病理生理杂志2001，Vol.17Issue(3)：230-234,5.
川芎嗪对实验性心肌缺血再灌注损伤中
一氧化氮和内皮素的干预
Effect of ligustrazini on nitric oxide and endothelin
in the reperfusion injury after myocardial ischemia in rabbits
王万铁 1徐正礻介 1林丽娜 2王卫 1李东 3王宗敏4
作者信息
- 1. 温州医学院 病理生理教研室
- 2. 温州医学院 附属一院麻醉科
- 3. 温州医学院 检验系分析中心
- 4. 温州医学院 附属二院病理科,
- 折叠
摘要
Abstract
AIM: To study the role of nitric oxide and endothelin in myocardial ischemia-reperfusion injury (MIRI) and effect of ligustrazini (LGT). METHODS: The rabbits were randomly divided into three groups (n=10, in each ),sham operated group( A ),MIR group( B ) and LGT group(C).Plasma nitric oxide products( NOP,in terms of NO-2/NO-3 ) contents,endothelin (ET) levels,and lactate dehydrogenase (LDH) activities were measured before ischemia, 40 minutes after ischemia and 20 minutes after reperfusion.Meanwhile NOP, ET concentrations and LDH activity in myocardium were measured ,and the ultrastructure changes in myocardium were observed under electron microscope at 20 minutes after reperfusion. RESULTS: As compared with group A,NOP decreased and ET as well as LDH increased at 40 minutes (P＜0.05 and P＜0.01) and more significant at 20 minutes after reperfusion (P＜0.01) in plasma ,and NOP and LDH decreased as well as ET increased(P＜0.05 and P＜0.01) at 20 minutes after reperfusion in myocardium and there were abnormal changes of the myocardial ultrastructure at 20 minutes after reperfusion ;LGT reversed the results of mentioned indices as above markedly. CONCLUSION: The ischemia-reperfusion results in dysfunction of the endothelium(NO level decreasing and ET level increasing) which is an important factor during MIRI,LGT reduces MIRI by protecting coronary endothlium(raising NO level and dropping ET level).关键词
心肌/再灌注损伤/一氧化氮/内皮缩血管肽类/川芎嗪分类
医药卫生引用本文复制引用
王万铁,徐正礻介,林丽娜,王卫,李东,王宗敏..川芎嗪对实验性心肌缺血再灌注损伤中
一氧化氮和内皮素的干预[J].中国病理生理杂志,2001,17(3):230-234,5.
