中国现代医学杂志2007，Vol.17Issue(19)：2310-2312,2321,4.
核仁组成区嗜银蛋白AgNOR在子宫内膜病变组织中的定量研究
Quantitative study on AgNOR in endometrial diseases
摘要
Abstract
[Objective] To investigate the usage of AgNOR in early diagnosis and prognosis of endometrial adenocarcinoma. [Methods] Experimental group: 107 cases including 25 of endometrial hyperplasia, 19 of atypical proliferation and 63 of endometrial adenocarcinoma. Control group: 25 cases of normal endometrium. Quantitative study and morphometric analysis of AgNORs were taken in different endometrial tissues with silver-staining technique. [Results] AgNORs count had no statistical differences (P＞0.05) in normal endometrium(2.51 ±1.97), endometrial hyperplasia (2.92±2.02) and atypical proliferation (3.04±2.05). In endometrial adenocarcinoma, AgNORs count increased obviously(7.43±2.18), which was higher than benign diseases [endometrial hyperplasia (2.92±2.02), atypical proliferation (3.04±2.05)] and control group (2.51 ±1.97) prominently (P ＜0.05). AgNORs count increased with grade of cellular differentiation (4.69±2.32), (5.38±2.99), (7.54±2.09), clinical phase(3.68±3.16), (4.53±2.94), (7.27±2.84), (7.84±2.33) and lymphatic metastasis (7-68±2.42), (3.62±3.27) (P ＜0.05). AgNORs morphometrics changed from simple type to dispersed type with the progression of endometrial diseases. [Conclusions] The quantitative study and morphometric analysis of AgNORs were correlated to the incidence of endometrial adenocarcinoma, and it could provide evidence for diagnosis of endometrial adenocarcinoma and could be used as a prognostic index in malignancies.关键词
AgNOR/子宫内膜痛变/子宫内膜腺癌Key words
endometrial diseases/ AgNOR/ endometrial adenocarcinoma分类
医药卫生引用本文复制引用
马晓欣,金英楠,赵艳辉,苗青,张忠福,李晓晗..核仁组成区嗜银蛋白AgNOR在子宫内膜病变组织中的定量研究[J].中国现代医学杂志,2007,17(19):2310-2312,2321,4.基金项目
该课题获辽宁省2002年博士启动基金(20021036) （20021036）
