中国临床康复2005，Vol.9Issue(30)：232-233,2.
容量泵输注尿激酶对老年下肢闭塞性动脉硬化患者下肢静息痛、间歇跛行及行走距离的影响
Effect of urokinase injected by volumetric infusion pump on rest pain, intermittent limp and walking distance in aged patients with arteriosclerosis obliterans of the lower limbs
杨文 1初荣 1王玉 1曾倩 1刘淑荣 1罗宁 1杨鸿雁 1汤北1
作者信息
- 1. 解放军沈阳军区总医院第二干部病房,辽宁省沈阳市,110016
- 折叠
摘要
Abstract
BACKGROUND: Arteriosclerosis obliterans of the lower limbs often manifests such symptoms as cold, numb, pain and ulcer in the limbs. For severe cases, necrosis of limbs appears, which severely affects the motor function of the lower limbs.OBJECTIVE: To observe the improving effect of urokinase injected by volumetric infusion pump on the pain of lower limbs and walking function in patients with ischemic limbs due to arteriosclerosis obliterans.DESIGN: A randomly grouping and controlled observation SETTING: Second Carder's Ward, General Hospital of Shenyang Military Area Command of Chinese PLAPARTICIPANTS: Totally 77 cases of arteriosclerosis obliterans of lower limbs diagnosed at the Second Carder's Ward of General Hospital of Shenyang Military Area Command of Chinese PLA from January 2000 to December 2003 were recruited. The patients were randomly divided into the treatment group (n=35) and the control group (n=42).METHODS: For treatment group, (500-700) ×104 U of urokinase was injected into forearm intravenously, 10×104 U each hour, and the administration time was decided according to the improvement of the symptoms. 5 to 8 days was one course of treatment. For the control group, 30 mL of compound danshen root (Radix Salviae Miltiorrhizae) was injected intravenously, once a day, and 15 days in total.MAIN OUTCOME MEASURES: The improvement in rest pain, numbness, intermittent limp and walking distance of the lower limbs after the treatment in the two groups as well as the adverse effects.RESULTS: According to intention-to-treat analysis, 77 patients of the two ×104U of urokinase [(50-70)×104 U] was injected by volumetric infusion pump every day for the treatment group, and the treatment lasted for (7 ±3.6)days ( 5-11 days). For the control group, compound danshen 30 mL×15 days groups: the elimination rate of rest pain in the treatment group was significantly higher than in the control group [75% (9/35) ,30%(3/42) ,x2 = 4.45,P ＜ 0.05]. The rate of improvement of intermittent limp was significantly higher in the treatment group than in the control group [80.8%(17/35),39.1%(9/42) ,x2 = 8.91,P ＜ 0.01].Walking distance was significantly longer in the treatment group than in the control group [(120.2 ± 23.5), (76.5CONCLUSION: Injection of urokinase by volumetric infusion pump can control the dosage of each hour and improve the chronic ischemia symptoms of the limbs. Rest pain of 75% patients disappeared. Intermittent limp and walking distance of 80% patients and function of lower limbs of the patients were significantly improved. Hemorrhage was not found.关键词
输注泵/动脉硬化/老年人/缺血/下肢/疼痛/间歇性跛行分类
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杨文,初荣,王玉,曾倩,刘淑荣,罗宁,杨鸿雁,汤北..容量泵输注尿激酶对老年下肢闭塞性动脉硬化患者下肢静息痛、间歇跛行及行走距离的影响[J].中国临床康复,2005,9(30):232-233,2.
