中国药科大学学报2008，Vol.39Issue(3)：232-237,6.
CS-HPLC-ESI-MSn法分析复方丹参滴丸的代谢指纹图谱
Metabolic fingerprint and profile analysis of compound Danshen dripping pills by CS-HPLC-ESI-MSn
摘要
Abstract
Aim: To establish the metabolic fingerprint and profile of bioactive components in human plasma after sublingual administration of compound Danshen dripping pills. Methods: Human plasma samples were collected at different time intervals. Powerlab tension system was used to measure their ability of expanding blood vessel and column switching system was employed to purify and enrich the components of interest. Results: The plasma sample of 1.5h had the strongest ability for expanding blood vessel, and had five new peaks in the chromatogram. Conclusion: After being identified, the intensity ratio of these 5 peaks was calculated. The diagram called metabolic profile was established to link bioactive compounds with pharmacodynamic action.关键词
电喷雾质谱/代谢指纹图谱/复方丹参滴丸/药效作用Key words
electrospray mass spectrometry/ metabolic fingerprint/ compound Danshen dripping pills/ pharmacodynamic action分类
医药卫生引用本文复制引用
房敏峰,郑晓晖,王世祥,赵新锋,卫引茂,郑建斌..CS-HPLC-ESI-MSn法分析复方丹参滴丸的代谢指纹图谱[J].中国药科大学学报,2008,39(3):232-237,6.基金项目
This work was supported by the Key Scientific Project, Ministry of Education PRC (N0. 207151) （N0. 207151）
the Key Research Project of Shaanxi Province (N0. 2006Kz10-G5) （N0. 2006Kz10-G5）
