摘要
Abstract
Objective:To investigate ESWT's influences on the expression of VEGF in bonycallus,and the further effect of ESWT's mechanism about how to cure bone defect.Methods:IS Chinese healthy domestic rabbits were made the animal models of the double radial bone defection and damage,right upper extremity was experiment set,left upper extremity was matched control,after the wound healed about a week,right upper extremity enforce ESWT under general anesthesia,carry to correspond part at the bone defection and damage two pieces,the left opper extremity did't do it. Then we took X-ray photo to observe condition of bone defection after 4 weeks and 6 weeks. And taking the bone defection' s bony callus organization specimen; we would do histology-checking to observe organization propagate of cell circumstance,and do immunohistochem-istry -checking to observe expression of VEGF.Results:The content of VEGF in the osteoblast of the Extracorporeal shock wave treatment set be more obvious than the matched team,bone cell,fibroblast,blood capillary,osteoblast, mesenehymal of ESWT set increased actively.Conclusion:The VEGF's expression can be boosted under the ESW's stimulation, make the cell propagate to divide and help the bone defect to heal.关键词
ESW/成骨细胞/血管内皮细胞生长因子/骨缺损Key words
Extracorporcal shock wave(ESW)/Osteoblast/Vaseular endothelial growth factor(VEGF)/Bone defection分类
医药卫生
