中国现代医学杂志2004，Vol.14Issue(13)：23-26,4.
卡托普利对野百合碱诱发肺动脉高压的影响
Effect of captopril on monocrotaline - induced pulmonary hypertension
胥方元 1何成松 1邹树芳 1干锦华 1孔古娅2
作者信息
- 1. 四川泸州医学院附属医院,四川,泸州,646000
- 2. 四川大学华西基础医学院,四川,610041
- 折叠
摘要
Abstract
Objective:To investigate the effect of captopril on monocrotaline - induced pulmonary hypertension in rats. Methods:Adult male Waister rats were given a single dose of monocrotaline(50 mg/kg) to induce the mold of pulmoanry hypertension. 33 cases were randmonly divided into normal control group, mold group and captopril treatment group(n = 11 ). Then treated with gastric infusion of normal saline, captopril respectively for 21 days. The parameter of pulmonary hemodynamics was monitored by Gould 3 400 polygrph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio, the lung wet weight were measured. The level of plasma endothetin - 1 was determined by the method of nonequilibrium. Results: Captopril significantly inhibited the progression of pulmonary artery pressure(P ＜0.01 ). It decreased the right heart index, and reduced the lung wet weight and the level of plasma endothelin - 1 (P ＜0.05 ,or P ＜0,01 ). Conclusions:Captopril is able to reduce the pulmonary hypertension and improve the heart function. Its mechanisms may be related to reducing the level of plasma endothelin - 1.关键词
卡托普利/肺动脉高压/野百合碱/内皮素-1Key words
captopril/pulmonary hypertension/monocrotaline/endothelin - 1分类
医药卫生引用本文复制引用
胥方元,何成松,邹树芳,干锦华,孔古娅..卡托普利对野百合碱诱发肺动脉高压的影响[J].中国现代医学杂志,2004,14(13):23-26,4.
