肿瘤防治研究2001，Vol.28Issue(3)：234-236,3.
国产奥沙利铂治疗晚期大肠癌临床验证研究
Trial of Domestic-made Oxaliplatin in Patients with Advanced Colorectal Carcinoma
陈凌翔 1陈嘉 1郑秀立 1秦叔逵 2王雅杰 3王杰军 4陈振东 5宋恕平 6张灿珍 7吴昌平 8胡岳棣 9华东 10龚振夏 11邱少敏12
作者信息
- 1. 江苏省肿瘤防治研究所,南京 210009
- 2. 南京解放军八一医院
- 3. 上海第二军医大学附属长海医院
- 4. 上海第二军医大学附属长征医院
- 5. 安徽医科大学附属医院
- 6. 山东省肿瘤防治研究院
- 7. 云南省肿瘤医院
- 8. 常州市第一人民医院
- 9. 常州市肿瘤医院
- 10. 无锡市第四人民医院
- 11. 南通市肿瘤医院
- 12. 南京市肿瘤医院
- 折叠
摘要
Abstract
Objective The aim of this project was to evaluate the efficacyand adverse effects of Oxaliplatin(L-OHP) in advanced colorectal cancer(ACRC). Methods A randomized study of this drug versus combination with 5-FU/FA in ACRC patients was conducted in 12 hospitals. Arm A with L-0HP Arm B is a group contrasted with cisplatin, Tumor assessment dosdone every 2 cycles and responders were confirmed four weeks later.Results 78 ACRC patients entered the study, 74 cases evaluable for efficacy, the response rate for arm A and B of ACRC was 28.95%(11/38) and5.56%(2/36)(P<0.01). The main adverse effects were nauseu and vomiting ,alopecia and neuro-sensory toxicity.Conclusion The response rate in ACRC of domestic-made L-OHP was encouraging and comparable with eloxatin, The response rate was better than arm B of cisplatin.关键词
大肠癌/奥沙利铂/氟脲嘧啶/甲酰四氢叶酸钙/顺铂分类
医药卫生引用本文复制引用
陈凌翔,陈嘉,郑秀立,秦叔逵,王雅杰,王杰军,陈振东,宋恕平,张灿珍,吴昌平,胡岳棣,华东,龚振夏,邱少敏..国产奥沙利铂治疗晚期大肠癌临床验证研究[J].肿瘤防治研究,2001,28(3):234-236,3.
