河南医科大学学报2001，Vol.36Issue(3)：235-240,6.
兔不同动脉多巴胺受体亚型的比较
Comparison of the dopamine receptor subtypes in different arteries of rabbit
朱琳 1赵荣瑞 2冯羡菊 3曲凌波4
作者信息
- 1. 河南医科大学第一附属医院药剂科
- 2. 山西医科大学生理学教研室
- 3. 河南医科大学第一附属医院检验科
- 4. 郑州大学化学系
- 折叠
摘要
Abstract
Aim:To study the subtypes and functional significance of dopamine (DA)receptors in different rabbit arteries in vitro.Methods:Responses of preconstricted vascular rings to selective DA receptor agonists and antagonists were examined.Results:①The efficacy and potency of fenoldopam in inducing relaxation varied comsiderably with different vessels.The relexation responses of renal and mesenteric arteries were most the potent to fenoldopam,but the pulmonary artery was weaky responded to fenoldopam,femoral artery showed no response to fenoldopam.②PBDA induced concentration-dependent relaxations in all the vessels studied.However,anong the four vessels the mes enteric and femoral arteries showed most potent relexations to PBDA;renal and pulmonary arteries showed weak responses to PBDA.③Among the vessels studied,only pulmonary artery showed endothelium-dependent relaxing response to DA agonists;and ④the existence of DA2 receptors in mesenteric and femoral arteries was further evidenced in 6-OHDA treated rabbits.Conclusions:DA receptors subtypes are distributed in different vascular beds.To clarify the heterogeneity in subtype and responsiveness of DA receptors in the peripheral circulation may help to evaluate the physiological significance of DA receptors in the four vascular beds.关键词
多巴胺受体/血管舒张/Fenoldopam/Propylbutyl-dopamine/SCH23390/Dompridone分类
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朱琳,赵荣瑞,冯羡菊,曲凌波..兔不同动脉多巴胺受体亚型的比较[J].河南医科大学学报,2001,36(3):235-240,6.
