中华医学杂志（英文版）2008，Vol.121Issue(23)：2374-2378,5.
Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction
Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction
LIU Yu 1CHI Yong-hui 1LI Qiang 1ZHANG Da-peng 1WU Xiao-qing 1SUN Hao 1GUO Zong-sheng 1WANG Le-feng 1YANG Xin-chun 1GE Yong-gui 1WANG Hong-shi 1XU Li 1LI Wei-ming 1NI Zhu-hua 1XIA Kun1
作者信息
- 1. Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China
- 折叠
摘要
Abstract
Background The clinical outcome of percutaneous coronary intervention (PCI) is poorer in women than that in men.This study aimed at comparing the impact of gender difference on the strategy of primary PCI in patients with acute ST-segment elevation myocardial infarction (STEMI).Methods Two hundred and fifty-nine patients with STEMI who underwent primary PCI within 12 hours of symptom onset were enrolled.The male group consisted of 143 men aged >55 years,and a female group included 116 women without age limitation.Procedural success was defined as residual stenosis <20% with thrombolysis in myocardial infarction flow grade>2 and without death,emergency bypass surgery or disabling cerebral events during the hospitalization.The rate of major adverse cardiac events (MACE),including death,nonfatal myocardial infarction and target vessel revascularization during follow-up,was recorded.Results Female patients were more hypertensive and diabetic and with fewer cigarette smokers than male counterparts.The prevalence of angiographic 3-vessel disease was higher in the female group,but the procedural success rate was comparable between the two groups (94.4% vs 92.2%).The occurrence rate of MACE did not differ during the hospitalization (4.2% vs 6.0%,P=0.50),but was significantly higher in the female group during follow-up (mean (16.0±11.2) months) than that in the male group (5.4% vs 0.7%,P=0.02).Conclusion Despite a similar success rate of primary PCI and in-hospital outcomes in both genders,female patients with acute STEMI still have a worse prognosis during the long-term follow-up.关键词
gender/myocardial infarction/percutaneous coronary intervention/outcomesKey words
gender/myocardial infarction/percutaneous coronary intervention/outcomes分类
医药卫生引用本文复制引用
LIU Yu,CHI Yong-hui,LI Qiang,ZHANG Da-peng,WU Xiao-qing,SUN Hao,GUO Zong-sheng,WANG Le-feng,YANG Xin-chun,GE Yong-gui,WANG Hong-shi,XU Li,LI Wei-ming,NI Zhu-hua,XIA Kun..Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction[J].中华医学杂志（英文版）,2008,121(23):2374-2378,5.
