解放军医学杂志2001，Vol.26Issue(4)：238-240,3.
骨髓基质成骨细胞-松质骨基质复合人工骨肌袋移植的成骨作用
INTRAMUSCULAR BONE FORMATION BY IMPLANTATION OF COMPOSITE MARROW STROMAL OSTEOBLAST-CANCELLOUS BONE MATRIX ARTIFICIAL BONE
陶凯 1毛天球 1杨维东 1陈富林 1顾晓明 1陈书军1
作者信息
摘要
Abstract
The marrow stromal cells of adult New Zealand rabbits cultivated and induced in vitro were used to form MCCAB by mixing，seeding and solidifying methods with the aid of alginate. The MCCABs were auto-transplanted intramuscularly into the rabbits for 4 to 8 weeks. The alginate-cancellous bone matrix composites or the cancellous bone matrix alone were implanted as control. The effectiveness of bone formation was assessed by means of roentgenography and histology.The results showed that the osteogeneses of MCCABs were better than those of the alginate-cancellous bone matrix composites and of the cancellous bone matrix. In the MCCABs, both intramembranous and cartilaginous osteogenesis were seen with the former predominating. In the control, only slight cartilaginous osteogenesis was seen. The results suggested that the osteogenesis of the MCCABs constructed by using tissue engineering method was obvious when transplanted intramuscularly, therefore, this kind of tissue-engineered bone could be an effective way for clinical application.关键词
组织工程/骨髓基质成骨细胞/松质骨基质分类
医药卫生引用本文复制引用
陶凯,毛天球,杨维东,陈富林,顾晓明,陈书军..骨髓基质成骨细胞-松质骨基质复合人工骨肌袋移植的成骨作用[J].解放军医学杂志,2001,26(4):238-240,3.
