中华医学杂志（英文版）2008，Vol.121Issue(23)：2392-2396,5.
Clinical and angiographic characteristics of premenopausal women with coronary artery disease
Clinical and angiographic characteristics of premenopausal women with coronary artery disease
DOU Ke-fei 1CHEN Ji-lin 1QIAO Shu-bin 1LI Jian-jun 1QIN Xue-wen 1LIU Hai-bo 1WU Yong-jian 1CHEN Jue 1YAO Min 1YOU Shi-jie 1YUAN Jin-qing 1XU Bo 1DAI Jun 1YANG Yue-jin 1L(U) Rong 1QIU Hong 1YANG Wei-xian 1MU Zhao-wei 1GAO Run-lin 1GAO Zhan1
作者信息
- 1. Department of Cardiology,Cardiovascular Institute and Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China
- 折叠
摘要
Abstract
Background Coronary artery disease (CAD) is generally considered as a disease of middle-aged men.It is widely accepted that the risk for CAD of premenopausal women is low because of hormone protection.Based on our clinical experience，more and more premenopausal women suffer from angina and myocardial infarction without adequate concern.Even now，there are still limited detailed data to describe the characteristics，mechanism and prognosis of premenopausal CAD patients.This article aimed to analyze the clinical and angiographic characteristics of premenopausal women with CAD.Methods A total of 565 premenopausal women and 721 postmenopausal women (56-60 years old) who underwent coronary angiography for the first time from April 2004 to December 2007 were enrolled.The clinical data and coronary angiographic characteristics (presence，localization，length and severity) were compared between the premenopausal and postmenopausal CAD groups.Results Premenopausal CAD patients presented less frequently with hypertension，diabetes mellitus and dyslipidemia compared with postmenopausal CAD patients (55.0% vs 66.0%，15.0% vs 31.5%，23.9% vs 37.4%，respectively; all P<0.05).Although we found more frequent involvement of single vessel in premenopausal CAD (43.2% vs 26.9%，P=0),and triple vessels in postmenopausal (56-60 years old) CAD patients (33.8% vs 20.4%，P=0)，much more severe lesions (≥90%) at left main (2.9% vs 1.1%,P=0.048) and proximal left anterior descending artery (LAD) (28.2% vs 16.6%，P=0) in the premenopausal CAD group were found.Conclusion Premenopausal women with chest discomfort are always found to have obvious atherosclerosis，more inclined to be located at the left main and proximal LAD，which is a strong predictor of an adverse clinical outcome.关键词
coronary artery disease/premenopause/coronary angiography/characteristicsKey words
coronary artery disease/premenopause/coronary angiography/characteristics分类
医药卫生引用本文复制引用
DOU Ke-fei,CHEN Ji-lin,QIAO Shu-bin,LI Jian-jun,QIN Xue-wen,LIU Hai-bo,WU Yong-jian,CHEN Jue,YAO Min,YOU Shi-jie,YUAN Jin-qing,XU Bo,DAI Jun,YANG Yue-jin,L(U) Rong,QIU Hong,YANG Wei-xian,MU Zhao-wei,GAO Run-lin,GAO Zhan..Clinical and angiographic characteristics of premenopausal women with coronary artery disease[J].中华医学杂志（英文版）,2008,121(23):2392-2396,5.
