中国组织工程研究与临床康复2008，Vol.12Issue(12)：2396-2400,5.
骨髓间充质干细胞在软骨缺损修复中的应用
Bone marrow mesenchymal stem cells for repairing cartilage defect
王海芸 1张积礼 1武喆 2夏亚一2
作者信息
- 1. 敦煌市医院骨科,甘肃省敦煌市,736200
- 2. 兰州大学第二医院骨科研究所,甘肃省兰州市,730000
- 折叠
摘要
Abstract
BACKGROUND: Bone marrow mesenchymal stem cells are prospective used in cartilage tissue engineering due to easy acquire and plentiful amplification in vitro in a short term.OBJECTIVE: To summarize the application of bone marrow mesenchymal stem cells in repairing cartilage defect.RETRIEVAL STRATEGY: A computer-based online search was conducted in Pubmed for English language publications containing the key words of "marrow; mesenchymal stem cells; cartilage defect" from October 1982 to December 2006, Relevant data were also searched in China Scientific and Technological Achievement Database for Chinese language publications containing the key words of "marrow; mesenchymai stem cells; cartilage defect" from October 1982 to December 2006. There were 126Exclusion criteria: duplicated articles.LITERATURE EVALUATION: Literatures including reviews and experimental studies were mainly derived from Pubmed database and China Scientific and Technological Achievement Database.DATA SYNTHESIS: It has been proved that bone marrow mesenchymal stem cells could differentiate into cartilage in vivo.However, differentiation of cartilage phenotype in vitro was restricted by multiple factors, and the controlling mechanism is still unclear up to now. Animal experiments demonstrated that bone marrow mesenchymal stem cells could repair bone and cartilage defect. Although studies on bone marrow mesenchymal stem cells and cartilage tissue engineering have developed to a certain degree, clinical applications and evaluations, including cell marks of bone marrow mesenchymal stem cells in different differentiated stages, controls of proliferation and differentiation of bone marrow mesenchymal stem cells, and gene transfection technique, still need a further study.CONCLUSION: Animal experiments indicate that bone marrow mesenchymal stem cells can significantly repair bone and cartilage defect. Although studies on bone marrow mesenchymal stem cells and cartilage tissue engineering have developed to a certain degree, problems of bone marrow mesenchymal stem cells in basic and clinical researches still need to be solved further.关键词
骨髓/间充质干细胞/软骨缺损分类
医药卫生引用本文复制引用
王海芸,张积礼,武喆,夏亚一..骨髓间充质干细胞在软骨缺损修复中的应用[J].中国组织工程研究与临床康复,2008,12(12):2396-2400,5.
