中德临床肿瘤学杂志（英文版）2007，Vol.6Issue(1)：2-4,3.
调强放疗联合NP方案同步与序贯治疗中晚期非小细胞肺癌的疗效观察
Clinical study on concurrent and sequential therapy of intensity modulated radiation therapy (IMRT) combined with NP regimen chemotherapy in the treatment of middle and advanced non-small cell lung cancer
摘要
Abstract
Objective: To evaluate the clinical effects of concurrent and sequential therapy for middle and advanced stage non-small cell lung cancer (NSCLC) useing IMRT combined with NP regimen chemotherapy.Methods: Eighty patients with middle and advanced stage NSCLC were randomized into two groups. Forty patients were underwent sequential therapy and other 40 patients were underwent concurrent therapy. IMRT was used in radiotherapy and NP regimen of vinorelbine+cispatin(NP) was used in chemotherapy. Results: (1) The overall response (CR+PR) rate was 75% in concurrent group and 45% in sequential group (P＜0.05); (2) The treatment courses were 84 days and 140 days for concurrent group and sequential group respectively (P＜0.05); (3) One-year survival rate in concurrent group was 72.4% and 52.3% in sequential group respectively;(4) The toxic effects can be tolerable by all of patients. Conclusion: The concurrent chemo-radiotherapy has better overall response, one-year survival rate and shorter treatment course than the sequential chemo-radiotherapy, so it is a better method for the treatment of middle and advanced stage NSCLC, but the long term survival rate will be studied.关键词
non-small cell lung cancer (NSCLC)/intensity modulated radiation therapy (IMRT)/chemotherapy/concurrent therapy/sequential therapyKey words
non-small cell lung cancer (NSCLC)/intensity modulated radiation therapy (IMRT)/chemotherapy/concurrent therapy/sequential therapy分类
医药卫生引用本文复制引用
Xiaodong Jiang,Da'an Song,Weiming Zhang,Jin Wu..调强放疗联合NP方案同步与序贯治疗中晚期非小细胞肺癌的疗效观察[J].中德临床肿瘤学杂志（英文版）,2007,6(1):2-4,3.基金项目
Supported by a grant from Health Bureau of Lianyungang City's Fund Program (No. 05051). （No. 05051）
