中国病理生理杂志2003，Vol.19Issue(2)：240-243,4.
内源性精氨酸加压素在索曼引起的大鼠体温降低中的作用
Role of endogenous arginine vasopressin in soman-induced hypothermia in rats
摘要
Abstract
AIM: This study was designed to examine whether endogenous arginine vasopressin (AVP) is involved in soman-induced hypothermic process. METHODS: Core temperature was measured at 60 min intervals with digital thermometer. Effect of AVP V1 receptor antagonist (30 μg/kg, ip) on soman-induced hypothermia was observed in rats, and plasma AVP concentration was measured at 2 h after administration of soman(60 μg/kg, sc). RESULTS: Administration of soman led to a marked hypothermia. Core temperature recovered to basal levels at 7 h after soman treatment. Plasma AVP concentration increased markedly at 2 h after soman treatment, and administration of AVP V1 receptor antagonist markedly blocked the hypothermic effect of soman. CONCLUSION: The data indicate that AVP is involved in soman-induced hypothermia in the rat.关键词
索曼/精氨酸加压素/低温/大鼠Key words
Soman/Arginine vasopressin/Hypothermia/Rats分类
医药卫生引用本文复制引用
杨永录,刘丽华,张影..内源性精氨酸加压素在索曼引起的大鼠体温降低中的作用[J].中国病理生理杂志,2003,19(2):240-243,4.基金项目
Medical and Pharmaceutical Foundation of PLA (No.96M033) （No.96M033）
