中国现代医学杂志2005，Vol.15Issue(16)：2410-2413,2420,5.
辽宁中年汉族人群IRS-2G1057D突变筛查及其意义
Study on G1057G polymorphisms of IRS-2 gene and its significance in middle-aged healthy population in liaoning
摘要
Abstract
[Objective] To investigate the G1057D polymorphism of insulin receptor substrate-2 (IRS-2) and its significance in Chinese Han middle-aged healthy population in Liaoning. [Methods] G1057D variants of IRS-2 were detected by PCR-RFLP in 221 normal subjects aged 40 to 60 years old, including 113 obese subjects and 108 non-obese subjects. The relationship between G1057D variants of IRS-2 and these parameters was analyzed. [Results] The frequency of allele D of G1057D variant was 29.6% in total subjects with 24.3% in obese and 35.2% in non-obese subjects. FPG and 2h C-peptide level after OGTT were lower in subjects with DD genotype than with GG genotype in non-obese group (P ＜0.05, P ＜0.01), respectively, but HOMAB was higher was higher in subjects with DD genotype than with GG genotype in the same group. 2hCPeptide after OGTT and HOMAIR were higher in subjects with DD genotype than with GG genotype in obese group (P ＜0.01, P ＜0.01). WHR was higher in obese DD genotype group than obese GG genotype group (P ＜0.05). [Conclusion] The insulin sensitivity increases in nonobese subjects with DD genotype and decreases in obese, especially abdominal obese subjects with DD genotype,which indicate that DD genotype for G1057D of IRS-2 may play dual role in preventing and promoting development of type 2 diabetic mellitus in non-obese and obese healthy population.关键词
胰岛素受体底物-2/单核苷酸多态性/2型糖尿病/肥胖Key words
insulin receptor substrate-2/single nucleotide polymorphism/type 2 diabetes mellitus/obesity分类
医药卫生引用本文复制引用
孔令芳,刘亚莉,钱聪,侯永生,李强,刘国良..辽宁中年汉族人群IRS-2G1057D突变筛查及其意义[J].中国现代医学杂志,2005,15(16):2410-2413,2420,5.基金项目
Supported by Liaoniang science and technologyoffice tackle key problem foundation(2001225001-16) （2001225001-16）
