北京大学学报（医学版）2003，Vol.35Issue(3)：241-247,7.
外周电刺激抑制大鼠吗啡条件性位置偏爱的复发及海洛因成瘾者的心瘾
Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts
摘要
Abstract
SUMMARY Objective:To test the hypothesis that peripheral electric stimulation (PES) may suppress the reinstatement of morphine-induced conditioned place preference (CPP) in rats as well as the drug craving of detoxified heroin addicts in a frequency-dependent manner.Methods:CPP model of the rat was constructed with two compartment automatic CPP apparatus, and the craving of the heroin addicts was assessed with a visual analogue scale (VAS). Results:(1) PES of low frequency could prevent the drug priming- or foot shock-induced reinstatement of morphine CPP; (2) this effect was naloxone-reversible, suggesting a possible involvement of endogenous opioid mechanisms; and (3) PES of low frequency could also accelerate the rate of natural decay of drug craving in heroin addicts after successful abstinence. Conclusion:PES might serve as a therapeutic measure for the treatment of heroin addiction.关键词
吗啡/海洛因依赖/条件性位置偏爱/心瘾/经皮神经电刺激Key words
Morphine/Heroin dependence/Conditioned place preference/Drug craving/Transcutaneous electric nerve stimulation分类
医药卫生引用本文复制引用
王玢,张本国,葛学采,罗非,韩济生..外周电刺激抑制大鼠吗啡条件性位置偏爱的复发及海洛因成瘾者的心瘾[J].北京大学学报（医学版）,2003,35(3):241-247,7.基金项目
国家重点基础研究规划项目"脑功能和重大疾病的基础研究"(G1999054000),基础研究重大项目前期研究专项"阿片成瘾与复吸的神经机制及非药物抗复吸的研究"及美国国立卫生研究院基金资助 （G1999054000）
