中国临床康复2003，Vol.7Issue(17)：2416-2417,2.
Fas相关死亡域蛋白表达与增生性瘢痕演变的关系
Relationship between expression of Fas protein associated with death domain with development of hyperplastic scars
舒彬 1郝林林 1聂志容 1林永辉 1冯光锐 1吴宗耀2
作者信息
- 1. 解放军第三军医大学大坪医院康复医学科,重庆市,400042
- 2. 解放军第三军医大学西南医院康复医学科,重庆市,400038
- 折叠
摘要
Abstract
Aim To explore the change of in situ expression of FADD (Fas protein associated with death domain) at various stages in hypertrophic scars and its implication.Methods The change of expression of FADD genes at mature stage, proliferative stage and regressive stages in HS was quantitatively investigated by in situ hybridization techniques and imagine analysis system.Results Expressive intention of FADD genes at the mature stage[area density( 9.36± 0.92), average integral optical density( 1154± 68)〗 was 2 times as that at the proliferative stage[area density( 4.72± 0.35), average integral optical density( 552± 32)〗 ,and 5 times as that at regressive stage[area density( 1.88± 0.12), average integral optical density( 218± 16)〗 .Staining sites located in the stratum spinosum of epidermis,reticular dermis and part vessels.Conclusion FADD expression is tightly associated with the development of hypertrophic scars. 关键词
瘢痕/基因表达/原位杂交Key words
cicatrix/gene expression/in situ hybridization分类
医药卫生引用本文复制引用
舒彬,郝林林,聂志容,林永辉,冯光锐,吴宗耀..Fas相关死亡域蛋白表达与增生性瘢痕演变的关系[J].中国临床康复,2003,7(17):2416-2417,2.
