中德临床肿瘤学杂志（英文版）2004，Vol.3Issue(1)：24-28,5.
细胞周期素D1、Ki67在鼻咽癌中的表达及意义
Significance of the Expression of CyclinD1 and Ki67 Antigen in Nasopharyngeal Carcinoma
胡国清 1石小燕1
作者信息
- 1. 武汉华中科技大学同济医学院附属同济医院肿瘤中心,430030
- 折叠
摘要
Abstract
Objective: To detect the expression of cyclinD1 and Ki67 in nasopharyngeal carcinoma (NPC) and their correlation with the biological behaviors and prognosis. Methods: 56 cases of biopsy specimens of NPC which had been embedded with paraffin in 1996 in our hospital were collected and immunostained with cyclinD1 and Ki67 monoclonal antibodies by means of the streptavidin peroxides method. The patients were followed up periodically, and then their biological behaviors and prognosis were statistically analyzed.Results: The percentage of cyclinD1 and Ki67 positive cells in the NPC specimens ranged from 0-54% and 0-31% respectively. The staining was nuclear. Of the 56 cases, 30 cases (56.6%) highly expressed cyclinD1 or Ki67 HPI and 26 cases (46.4%) lowly expressed cyclinD1, while only 16 cases (28.6%) showed Ki67 HPI(high proliferated index) and 40 cases (71.4%) showed Ki67 LPI (low proliferated index). Patients who lowly expressed cyclinD1 or highly expressed Ki67 had a higher radiosensitivity and a better prognosis.Conclusion: CyclinD1 and Ki67 immunohistochemical staining is considered to be useful, not only as an independent factor of radiosensitivity and prognosis respectively, but also as a means of determining the optimum treatment for each individual patient with NPC.关键词
细胞周期素D1(cyclin D1)/Ki67/鼻咽癌(NPC)Key words
cyclinD1/Ki67/radiosensitivity/prognosis/nasopharyngeal carcinoma分类
医药卫生引用本文复制引用
胡国清,石小燕..细胞周期素D1、Ki67在鼻咽癌中的表达及意义[J].中德临床肿瘤学杂志（英文版）,2004,3(1):24-28,5.
