中国现代医学杂志2007，Vol.17Issue(20)：2433-2436,4.
HBV携带产妇的血清及乳汁HBV-DNA载量的差异与母乳喂养安全性的研究
Load of HBV DNA in serum and breast milk of HBV carried mother and safety of breast-fed infants
摘要
Abstract
[Objective]To investigate the relationship between the load of HBV-DNA in serum and breast milk of pregnant women carrying HBV and the safety of breast-feeding and to explore the blocking effect on the mother-infant transmission of HBV.[Methods]Content of HBV-DNA and/or HBVM in serum and breast milk specimens of 91 pregnant women with positive HBsAg and HBeAg and in serum specimens of their 24 month old infants were detected by Real-time quantitative polymerase chain reaction(RQ-PCR)and/or EIA at the age of 3rd(T3),9th(T9),12th(T12),24th(T24)month old.32 infants were received by breast-feeding,59 infants were received by bottle-feeding. [Results]HBV-DNA positive rates in the blood and breast milk of pregnant women were 100% and 49.45%,respectively(P＜0.005). Their average concentrations of HBV-DNA were(7.43±1.81) and (4.02±1.01),respectively.The HBV-DNA level in serum of the pregnant women was correlated to the outletting rate of HBV-DNA in colostrum positively.The infective rates of HBV in the two group infants were 15.63% and 13.56%,respectively.There was no significant difference (X2=0.022,P＞0.05).The GMT of anti-HBs in breat fed group infants were higher than those of artifical fed group infants.[Conclusion]When the load of HBV-DNA in serum specimen of pregnants women with positive HBsAg and HBeAg was more than 109 copies/ml,their newborns were as a high risky population of HBV vertical transmission.Load of HBV-DNA in serum was less than 104 copies/ml in infants infected by HBV.The positive rate and the content of HBV-DNA in colostrum were less than those in serum obviously.After newborns of HBV positive mothers received the combined immunization of HBvac and HBIG,the breast feeding did not influence the blocking effect on mother-infant transmission of HBV and helped increasing the GMT of anti-HBsin blood of infants.关键词
HBV-DNA载量/乳汁/母乳喂养/人工喂养/母婴传播Key words
HBV-DNA load/breast milk/breast-feeding/bottle-feeding/mother-infant transmission分类
医药卫生引用本文复制引用
马力,王兆荃,赵桂珍,梁争论,王心竹..HBV携带产妇的血清及乳汁HBV-DNA载量的差异与母乳喂养安全性的研究[J].中国现代医学杂志,2007,17(20):2433-2436,4.基金项目
Supported by Nation "95" Important Topic of National Natural Science Fund Committee,China(No.96906-03-03) （No.96906-03-03）
