福建农林大学学报（自然科学版）2003，Vol.32Issue(2)：245-248,4.
从赤芝提取的氨基葡聚糖对大鼠实验性溃疡的保护作用
Protective effects of glycosaminoglycan isolated from Ganoderma lucidum on experimental ulcers in rats
摘要
Abstract
To investigate the protective effects of glycosaminoglycans (GAG) from Ganoderma lucidum on experimental ulcersin rats. GAG was isolated from the fruiting body of G. lucidum using a multi-step procedure and the resulting extract was i-dentified by chromatographic methods and chemical analyses of hydrolysates. Rat experimental ulcers were induced by stress(swimming in cold water for 30 min), administration of acetic acid or indomethacin, and ligation of gastric pylorus. GAG (0.5and 1.0 g @ kg-1) was dissolved in sterile water and administered by force-feeding (gastrogarage) immediately before ulcer-in-ducer administration or 30 min before the start of swimming in cold water and ligation of gastric pylorus. Control animals re-ceived the same amount of vehicle. Ranitidine (100 mg @ kg-1, p. o. ) was used positive control. The results indicated thatGAG had similar effects on the reduction of the ulcer formation and free gastric H+ levels (P＜0.001) compared with raniti-dine-treated group. The preventive effects appeared to be more marked in the acetic acid- and indomethacin-treated groups.These results indicate that GAG isolated from G. lucidum is an active polysaccharide component with ulcer-healing effects.Further studies are required to explore the mechanism of the action of GAG.关键词
赤芝/提取物/氨基葡聚糖/大鼠/实验性溃疡/保护作用Key words
Ganoderma lucidum/glycosaminoglycan/isolate/rat/experimental ulcer/protective effect分类
农业科技引用本文复制引用
高益槐,候建明,蓝进,唐文波,高鹤..从赤芝提取的氨基葡聚糖对大鼠实验性溃疡的保护作用[J].福建农林大学学报（自然科学版）,2003,32(2):245-248,4.基金项目
新西兰自然科学基金. （）
