中华医学杂志（英文版）2009，Vol.122Issue(3)：245-251,7.DOI:10.3760/cma.j.issn.0366-6999.2009.03.002
Diagnosis and treatment of melamine-associated urinary calculus complicated with acute renal failure in infants and young children
Diagnosis and treatment of melamine-associated urinary calculus complicated with acute renal failure in infants and young children
SUN Ning 1JIANG Ye-ping 2FENG Dong-chuan 2ZHANG Rui-feng 1ZHU Xiao-yu 3XIAO Hong-zhan 2SHEN Ying 1SUN Qiang 2LI Xu-ran 2JIA Li-qun 2ZHANG Gui-ju 4ZHANG Wei-ping 5CHEN Zhi 4FAN Jian-feng6
作者信息
- 1. Department of Urology Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
- 2. Department of Nephrology Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
- 3. Diagnostic Imaging Center Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
- 4. Department of Surgery Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, China
- 5. Department of Pediatric Internal Medicine Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, China
- 6. Beijing Institute of Microchemistry, Beijing 100091, China
- 折叠
摘要
Abstract
Background Infants in some areas of China developed urinary lithiasis after being fed with powdered milk that was tainted with melamine in 2008 and very small proportion of the infants developed acute renal failure caused by urinary tract calculus obstruction. The aim of this article was to summarize clinical characteristics, diagnosis and treatment of infants with urinary calculus and acute renal failure developed after being fed with melamine tainted formula milk.Methods Data of infant patients with urinary calculus and acute renal failure due to melamine tainted formula milk admitted to the Beijing Children's Hospital Affiliated to the Capital Medical University and the Xuzhou Children's Hospital in 2008 were used to analyze the epidemiological characteristics, clinical manifestations, imaging features as well as effects of 4 types of therapies.Results All the 34 infants with urinary calculus were complicated with acute renal failure, their blood urea nitrogen (BUN) was (24.1±8.2) mmol/L and creatinine (CO was (384.2±901.2) μmol/L. The chemical analysis on the urinary calculus sampled from 15 of the infants showed that the calculus contained melamine and acidum uricum. The time needed for the four types of therapies for returning Cr to normal was (3.5±1.9) days for cystoscopy group, (2.7±1.1) days for lithotomy group, (3.8±2.3) days for dialysis group, and (2.7±1.6) days for medical treatment group, which had no statistically significant difference (P=0.508). Renal failure of all the 34 infants was relieved within 1 to 7 days, averaging (3.00±1.78) days.Conclusions Melamine tainted formula milk may cause urinary calculus and obstructive acute renal failure. It is suggested that firstly the patients with urinary calculus complicated with acute renal failure should be treated with dialysis or medication to correct electrolyte disturbance, in particular hyperkalemia, and then relieve the obstruction with available medical and surgical methods as soon as possible. It was observed that the short-term prognosis was satisfactory.关键词
calculus, urinary/ renal failure, acute/ melamine/ infant/ childKey words
calculus, urinary/ renal failure, acute/ melamine/ infant/ child分类
医药卫生引用本文复制引用
SUN Ning,JIANG Ye-ping,FENG Dong-chuan,ZHANG Rui-feng,ZHU Xiao-yu,XIAO Hong-zhan,SHEN Ying,SUN Qiang,LI Xu-ran,JIA Li-qun,ZHANG Gui-ju,ZHANG Wei-ping,CHEN Zhi,FAN Jian-feng..Diagnosis and treatment of melamine-associated urinary calculus complicated with acute renal failure in infants and young children[J].中华医学杂志（英文版）,2009,122(3):245-251,7.
