中国临床康复2005，Vol.9Issue(4)：247-249,3.
石杉碱甲对 D-半乳糖致衰老小鼠学习记忆行为的影响
Effects of Huperzine A on the memory and learning behavior in D galactose induced senile mice
邱培勇 1陈正跃 1王永学 1张积霞 1吴子钊1
作者信息
- 1. 新乡医学院药物研究室,河南省新乡市,453003
- 折叠
摘要
Abstract
BACKGROUND:Huperzine A is a reversible choline enzyme(CHE) inhibitor initially developed in China,which has favorable therapeutic effectiveness in benign memory dysfunction,and could significantly promote the learning process and memory reappearance in rodent animals. OBJECTIVE:To comprehend the impacts of Huperzine A on the enhancement of learning, memory and behavior in platform and maze experiments in D Galoctose(Gal) induced senile mouse model. DESIGN:A randomized and controlled trial. SETTING:Institute of Pharmaceuticals of Xinxiang Medical College. MATERIALS:Study was performed in the Laboratory of Physiology and the Institute of Pharmaceuticals of Xinxiang Medical College from January to December in 2002.A total of 100 healthy Kunming mice were selected for platform and electric maze experiments with 50 mice in each experiment.Huperzine A tablet was obtained from Henan Zhulin Zhongsheng Pharmaceutical Company Limited(batch number:031001).D Gal is the product of Shanghai No.2 Reagent Factory. MAIN OUTCOME MEASURES:The latency in the safe area on the platform and the times of electric shock occurred within 5 minutes were observed in mice in platform experiment;the times of the mice mistakenly escaping to the right electric attacking area were observed in mice in electric maze experiment. CONCLUSION:Huperzine A can effectively improve the learning and memory ability of D Gal induced senile mice, and there is dose effect relationship within certain range. Qiu PY,Chen ZY,Wang YX,Zhang JX,Wu ZZ.Effects of Huperzine A on the memory and behavior in D galactose induced senile mice.Zhongguo Linchuang Kangfu 2005;9(4):247- 9(China) [www.zglckf.com]关键词
衰老/记忆/半乳糖分类
医药卫生引用本文复制引用
邱培勇,陈正跃,王永学,张积霞,吴子钊..石杉碱甲对 D-半乳糖致衰老小鼠学习记忆行为的影响[J].中国临床康复,2005,9(4):247-249,3.
