中国药理学与毒理学杂志2004，Vol.18Issue(4)：248-252,5.
γ-氨基丁酸对急性不完全性全脑缺血大鼠脑组织氨基酸和钙离子含量的影响
Effects of γ-aminobutyric acid on amino acids and calcium levels in rat brain of acute incomplete global cerebral ischemia
摘要
Abstract
AIM To explore further protection mecha nism of GABAergic drugs on cerebral ischemia.METHODS The acute incomplete global cerebral ischemia model was induced by ligation of bilateral common carotid arteries.The contents of amino acids were determined by high performance liquid chromatography combined withfluorescentdetection,Ca2 + level was measured with atomabsorptionspectrometry.RESULTS Cerebral ischemia for 4 h increaseglutamate( Glu )and aspartate(Asp) contents in hippocampus and cortex,and GABA content inhippocampus;elevated Ca2 + level;increased brain watercontent.Pretreatment with exogenous GABA(100mg·kg1,iv,30minbeforeischemia)markedly suppressed ischemia-induced release of Gluand Asp,reduced brain water content in cortex.Moreover,exogenous GABA increased endogenous GABA content in hippocampus.CONCLUSION GABA inhibits excessive efflux of excitatory amino acids,increases inhibitory amino acid level,and alleviates brain edema.关键词
脑缺血/γ-氨基丁酸/钙/脑水肿/海马/皮质Key words
cerebral ischemia/γ-aminobutyric acid/calcium/brain edema/hippocampus/cortex分类
医药卫生引用本文复制引用
欧阳昌汉,郭莲军,吕青,曲玲..γ-氨基丁酸对急性不完全性全脑缺血大鼠脑组织氨基酸和钙离子含量的影响[J].中国药理学与毒理学杂志,2004,18(4):248-252,5.基金项目
国家自然科学基金资助课题(30171082) （30171082）
