中国临床康复2003，Vol.7Issue(18)：2515-2517,3.
血脂紊乱对代谢综合征早期肾功能损害的影响
Influence of dyslipidemia on early renal functional lesions in patients with metabolic syndrome
摘要
Abstract
Aim To explore the influence of dyslipidemia on early renal functional lesions in patients with metabolic syndrome(MS).Methods 109 cases with essential hypertension (56 males and 53 females, EH group), 73 cases with diabetes mellitus (39 males and 34 females, DM group) and 175 cases with metabolic syndrome (87 males and 88 females, MS group) were respectively divided into two subgroups: normal lipid groups and dyslipidemia groups according to the serum total cholesterol(TC), triglycerides(TG), low density lipoprotein(LDL), and apolipoprotein B(Apo B) levels. The changes of renal function were observed and comparde between the subgroups of normal and dyslipidemia respectively.Results In the MS group, the concentration of microalbuminuria(MA) in the dyslipidemia group was(66± 3) mg within 24 hours, significantly higher than that of the normal group [(45± 4)mg,t=- 3.904,P< 0.01]; the endogenous creatinine clearance rate (Ccr) was (57± 3) mL/min in the dyslipidemia group, significantly lower than that in the normal group[(72± 4)mL/min,t=- 3.838,P< 0.01].But in the DM and EH groups,the concentrations of MA and Ccr were insignificantly different between the normal and dyslipidemia groups respectively. The correlation analysis showed that TC, LDL and ApoB only in the MS group were significantly related with MA and Ccr, and the TC played a most important role in MA and Ccr(r=0.3807, P< 0.01; r=0.3807, P< 0.05).Conclusion Dyslipidemia is one of the important factors inducing renal dysfunction in patients with MS when blood pressure and glucose are controlled at the same levels. Thus, serum lipid lowering therapy may be necessary to prevent deterioration of renal function in patients with metabolic syndrome.关键词
代谢疾病/胆固醇/甘油三酯类/蛋白尿Key words
metabolic disease/cholesterol/triglycerides/proteinuria分类
医药卫生引用本文复制引用
金玉华,祝之明,李彦社,闫振成,周方明,赵志刚..血脂紊乱对代谢综合征早期肾功能损害的影响[J].中国临床康复,2003,7(18):2515-2517,3.基金项目
国家自然科学基金资助项目 (39725013) （39725013）
