中国中西医结合杂志2001，Vol.21Issue(1)：25-27,3.
雷公藤多甙对哮喘患者T淋巴细胞亚群和血清白细胞介素-5浓度的影响
Effect of Tripterygium Polyglucoside on T-lymphocyte Subsets and Serum Interleukin-5 Level in Asthma Patients
摘要
Abstract
Objective: To investigate the therapeutic mechanism ofTripterygium polyglucoside (TⅡ) in treating asthma patients. Methods: Thirty asthma patients of middle or sever leoel were selected and randomly divided into three groups, Group A treated with TⅡ, Group B treated with prednisone and Group C, the control group. Their peripheral CD4＋, CD8＋ T-lymphocytes were counted by flow cytometer and serum interleukin-5 (IL-5) level determined by ELISA before and after 4 weeks′ treatment. Results: In Group A, after treatment, CD4＋ T-lgmphocytes reduced from 0.462±0.035 to 0.426±0.039 (P＜0.01), CD8＋ increased from 0.201±0.045 to 0.253±0.043 (P＜0.01), and serum IL-5 median concentration reduced from 65.3 ng/L to 10.9 ng/L (P＜0.01). Similar results was revealed in Group B, while there was insignificant change of the parameters in Group C. The serum concentration of IL-5 was positively correlated with the peripheral CD4＋ count (r＝0.61, P＜0.01). Conclusion: TⅡ is highly effective in treating asthma through regulating T-lymphocyte subset disorder and inhibiting production of IL-5.关键词
哮喘 雷公藤多甙 T淋巴细胞亚群 白细胞介素-5分类
医药卫生引用本文复制引用
王西华,张祖贻..雷公藤多甙对哮喘患者T淋巴细胞亚群和血清白细胞介素-5浓度的影响[J].中国中西医结合杂志,2001,21(1):25-27,3.基金项目
本课题受铁道部科研基金资助(No.TW97078) （No.TW97078）
