湖南中医学院学报2001，Vol.21Issue(2)：25-27,46,4.
脑血康口服液对实验性脑出血大鼠脑内一氧化氮生成的抑制作用
Inhibitory Effect of Naoxuekang Oral Liquid on Nitric Oxide Production in
Cerebral Cortex of Experimental Intracerebral Hemorrhage Rats
何纲 1黎杏群 1李学文 1梁清华 1张花先 1李霞玲 1陈昌华1
作者信息
摘要
Abstract
For the purpose of investigating the therapeutic mechanism of Naoxuekang oral liquid (NXK) in acute period of intracerebral hemorrhge (ICH),nitric oxide(NO) production in the cerebral cortex and neurological deficits of collagenase-induced ICH rats were observed,and distilled water (DW) treatment and sham operation were used separately as placebo and operation controls.The results showed that compared with those of sham-operated rats,the levels of NO in the cerebral cortex of DW-treated rats increased significantly 1d,2d,4d and 7d after operation(P＜0.01) and peaked 4d after operation,the scores of the neurological deficits of DW-treated rats were elevated remarkably(P＜0.05)，peaked 1d after operation,improved 2d after operation and approximately normalized 7d after operation.The inhibitory effects of L-NAME on brain NO production were superior to those of NXK,but the improvement of neurological deficits of the rats treated with NXK was more significant than that of the rats treated with L-NAME.These results suggest that the inhibition of NO production in the cerebral cortex might be one of the possible pharmacological mechanisms of NXK against ICH injury.关键词
脑血康口服液/活血化瘀/水蛭/脑出血/大鼠/一氧化氮分类
医药卫生引用本文复制引用
何纲,黎杏群,李学文,梁清华,张花先,李霞玲,陈昌华..脑血康口服液对实验性脑出血大鼠脑内一氧化氮生成的抑制作用[J].湖南中医学院学报,2001,21(2):25-27,46,4.
