中国病理生理杂志2001，Vol.17Issue(1)：25-28,4.
巴曲酶对狗心脏缺血/再灌注损伤中血栓素A2水平的影响
Effect of batroxobin on thromboxane level in canine with myocardial ischemia/reperfusion injury
郑直 1张勇刚 2符民桂 2夏春芳 2唐朝枢 2刘乃奎2
作者信息
- 1. 佳木斯中心医院心内科， 黑龙江 佳木斯 154002
- 2. 北京大学心血管研究所， 北京 100083
- 折叠
摘要
Abstract
AIM:To investigate the effect of batroxobin on thromboxaneA2（TXA2）level in canine heart ischemia/reperfusion (I/R) injury and the cardioprotective mechanism of batroxobin against I/R injury. METHODS: Canine heart ischemia was induced by ligation of the left anterior descending coronary artery for 30 min followed by 90 min reperfusion．Batroxobin was intravenously administered before heart ischemia and 15 min before reperfusion．The level of plasma thromboxane (TXA2) ，creatine phosphokinase (CK)， lactic dehydrogenase (LDH ) and the concentration of myocardial TXA2 were measured. The pathological changes in I/R myocardium were observed. RESULTS: In I/R group, TXA2 levels of both plasma and myocardium increased significantly，and myocardium was injured obviously. Myocyte cells of central zone of I/R heart showed intracellular edema, swollen and damaged mitochondria, and fragmentation of cristae and concentrated nucleus. Plasma CK and LDH level was also elevated. Both ways of batroxobin administration reduced TXA2 level apparently and plasma CK、LDH were also reduced significantly. LVEDP lowered while +dp/dt max elevated greatly，the mortality of I/R canine reduced obviously. CONCLUSION: Batroxobin decreased TXA2 levels of both plasma and myocardium significantly, and could afford protection from I/R injury.关键词
蛇毒凝血酶/局部缺血/再灌注损伤/心脏分类
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郑直,张勇刚,符民桂,夏春芳,唐朝枢,刘乃奎..巴曲酶对狗心脏缺血/再灌注损伤中血栓素A2水平的影响[J].中国病理生理杂志,2001,17(1):25-28,4.
