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Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population

Qian Zhang Fenhong Qian Linfu Zhou Guozhen Wei Ying Wang Zhibin Hu Guangfu Jin Jianling Bai Kaisheng Yin

南京医科大学学报(英文版)2009，Vol.23Issue(1)：25-32,8.

Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population

Qian Zhang ¹Fenhong Qian ²Linfu Zhou ³Guozhen Wei ²Ying Wang ⁴Zhibin Hu ²Guangfu Jin ¹Jianling Bai ⁵Kaisheng Yin⁶

作者信息

1. Department of Respiratory Medicine,Affiliated Changzhou No.2 People's Hospital,Nanjing Medical University,Changzhou 213003,China
2. These authors contributed equally to this work
3. Department of Respiratory Medicine,Affiliated Jiangbing Hospital,Jiangsu University,Zhenfiang 212001,China
4. Department of Respiratory Medicine,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,China
5. Department of Genetics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China
6. Department af Epidemiology and Biostatistics,Cancer Research Center,Nanjing Medical University,Nanjing 210029,China
折叠

摘要

Abstract

Objective:To evaluate the effects of polymorphisms in TLR7 and TLR8(as potential candidate genes) on asthma risk and asthma-related phenotypes.Methods:We consecutively recruited 318 unrelated adult asthmatic patients and 352 healthy volunteers from the same area of southeast China.Genotyping of each selected SNP was performed using multiplex PCR in conjunction with tagged array single base extension technology.We conducted case-control and case-only association studies between the selected SNPs in TLR7 and TLR8 and asthma or asthma-related phenotypes.Results:The T allele of rs5935436 SNP in TLR7 was protective from developing asthma in males (adjusted ORs=0.126,95% CIs=0.016-0.995).The CT/TT genotype of rs5935436 was less frequent in female asthmatics with allergic rhinitis (adjusted ORs=0.18,95% CIs=0.04-0.90).The homozygote AA of rs3761623 and GG of rs3764880 were positively associated with lower FEV1% and asthma severity in female asthmatics.These results were confirmed by haplotype analysis.Conclusion:TLR7 and TLR8 polymorphisms may play an important role in the pathogenesis of asthma that is gender-dependent.This could be clinically useful,both for identifying patients at risk of asthma and for preventing its occurrence.

关键词

Asthma/Atopy/Phenotype/Polymorphism/Toll-like receptors

Key words

Asthma/Atopy/Phenotype/Polymorphism/Toll-like receptors

分类

医药卫生

引用本文复制引用

Qian Zhang,Fenhong Qian,Linfu Zhou,Guozhen Wei,Ying Wang,Zhibin Hu,Guangfu Jin,Jianling Bai,Kaisheng Yin..Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population[J].南京医科大学学报(英文版),2009,23(1):25-32,8.

基金项目

This study was supported by grants from the National Natural Science Foundation of China 30400191 and 30570797. （）

南京医科大学学报(英文版)

ISSN：1674-8301

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