首页|期刊导航|中德临床肿瘤学杂志（英文版）|Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma
中德临床肿瘤学杂志（英文版）2006，Vol.5Issue(4)：253-256,4.
Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma
Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma
摘要
Abstract
Objective: Investigation of the relationship between P-glycoprotein (P-gp) and adhesion molecule CD44 as well as their clinical significance in gastric carcinoma. Methods: To examine the expressed level of P-gp and CD44 in 98 cases with gastric carcinoma by flow cytometry and evaluate their relationships with clinicopathological factors. Results: Among the 98 gastric carcinomas, 40 cases (40.8%)were P-gp negative (positive cells ＜25%); 14 cases (14.2%) were 25%-40% expression of P-gp positive cells;17 cases (17.3%) were 41%-60% expression of P-gp positive cells; 27 cases (27.5%) were the high expression(positive cells ＞60%) of P-gp in all patients with gastric carcinoma. When the tumor sizes were more than6 cm, the P-gp positive of CD44 showed a significant difference (P＜0.05) in 35 cases with P-gp positive,compared with it in 24 cases with P-gp negative. When the tumors were in low-moderate differentiated gastric carcinoma, the expression of CD44 showed a significant difference (P＜0.05) in 44 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients were in clinical Ⅲ-Ⅳ stage, the expression of CD44 showed a significant difference (P＜0.05) in 42 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients with lymph node metastasis, their CD44 expression showed a significant difference (P＜0.05) in 46 cases with P-gp positive, compared with it in 32 cases with P-gp negative. When the tumors P-gp expressed positive, their CD44 expression will be increase. Conclusion: When the CD44 and P-gp both have the positive high expression, it will be significantly associated with the gastric carcinoma progression and metastasis, so both were a positive expression in gastric carcinoma, it might suggest a poor and unfavorable prognosis result.关键词
gastric carcinoma/P-glycoprotein/CD44/FCMKey words
gastric carcinoma/P-glycoprotein/CD44/FCM分类
医药卫生引用本文复制引用
YU Chuanding,XU Shenhua,LING Yutian,ZHU Chihong,ZHOU Xinming,LIU Xianglin..Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma[J].中德临床肿瘤学杂志（英文版）,2006,5(4):253-256,4.基金项目
Supported by the ZheJiang Medical and Health Science Foundation (No. 2005A09). （No. 2005A09）
